How to treat
intrauterine adhesions /
Asherman syndrome

What are intrauterine adhesions,
how to treat them, protect your uterus

and regain hope for a pregnancy?

What are intrauterine adhesions / Asherman syndrome?

Intrauterine adhesions (IUA) or synechiae are fibrous bridges connecting the opposing walls of the uterus and closing the uterine cavity.

The Asherman's syndrome is the most complex form, obstructing the entire cavity.

IUA

Causes

The precise mechanism of their formation is unknown. Following a surgical intervention in the uterus, scarring of uterine wall tissue sometimes leads to the formation of IUA, regardless of the quality of the surgical procedure. IUA can appear after the following interventions:

Dilatation and curettage (D&C) for miscarriages, termination of pregnancy, retained products of conception
Myomectomy
Uterine septum surgery
Polypectomy

Symptoms

Symptoms that should alert you are the following:

Amenorrhea (having no periods)
Hypomenorrhea (very light periods)
Severe cramping or pain
Infertility (being unable to get pregnant)
Repeated miscarriages

Consequences

IUAs are the primary mechanical cause of infertility. They can also cause repeated miscarriages and obstetrical complications. There is higher rate of spontaneous abortion, as well as preterm delivery and abnormal placentation among patients with moderate to severe disease (1,2).

IUAs are very hard to remove and repeated surgical treatment may be required (3).

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How to diagnose
IUA

The best way to diagnose intrauterine adhesion is to perform a diagnostic hysteroscopy. During this procedure, your gynecologist places a small camera (a hysteroscope) through the cervix into the uterus to watch the entire uterine cavity and characterize the location, extent and type of adhesions. Diagnostic hysteroscopy can be performed in office and anesthesia is usually not required.

Treatment

The only treatment option is called adhesiolysis and it is an operation performed by an expert surgeon using hysteroscopy. The surgeon reaches the inside of the uterus through the cervix with a small camera to cut the adhesions with very small scissors or electrosurgery instruments. They can be difficult to eliminate completely and staged operations are sometimes necessary.

However, IUAs often grow back: the recurrence rate after intrauterine adhesiolysis can be as high as 62.5% in case of severe disease (4).

How to avoid IUA recurrence and increase chances of pregnancy

After surgery, it is critical to ensure that the two walls of your uterus don't touch each other, as it would facilitate the formation or recurrence of IUAs. Surgeons can place hyaluronic acid gels, contraceptive intrauterine devices (IUD) or the new Womed Leaf adhesion barrier inside your uterus as a preventative measure.

Four to six weeks later, a follow-up hysteroscopy is recommended to verify that your uterus has healed properly.

Womed Leaf

A new adhesion barrier

that can help protect your uterus to
get pregnant faster.

Womed Leaf is a soft and gentle film

that can be thought of as a womb dressing

Womed Leaf

How does Womed Leaf work?

The surgeon places the film inside your uterus at the end of the surgical procedure.

This flexible film grows between the walls of your uterus to prevent them from touching each other during the healing process.

After approximately one week, it will naturally come out with your vaginal discharge. You will not feel any discomfort or pain (5).

Womed Leaf is a medical device. It is a regulated health product which has received Medical CE Mark and can only be used by a healthcare professional.

She received Womed Leaf

Léa, 33 years old

"I was told I would not be able to have children again"

I was told that I would not be able to have children again. But since the operation and the insertion of the Womed Leaf, my periods have returned to the way they were before and I can have a spontaneous pregnancy. I am so happy and grateful to have benefited from this innovation.

Read Lea's testimony

Patient testimony

Patient resources

I want to benefit from Womed Leaf

List of hospitals where you can already benefit from Womed Leaf

France

CHU Bicêtre (Paris)
CHU Lariboisière (Paris)
Hopital La Conception (Marseille)
CHRU Jeanne de Flandre (Lille)
Clinique de La Sagesse (Rennes)
CHU Montpellier
CH Nîmes
CHU Clermont Ferrand

Belgium

Gent UZ

Czech Republic (coming soon)

General hospital (Prague)

Italy

AOU Federico II (Naples)
Aso Mauriziano Umberto I (Turino)

Spain

Ramon y Cajal Hospital University (Madrid)
Hospital Clinica (Barcelona)

Find out more

Womed Leaf is a medical device approved for sales in the EU and not in the United States. If you are an EU resident and received a prescription from your doctor, you can upload it and order Womed Leaf online on our pharmacist partner hyperpharma.com.

Order online