How to treat
intrauterine adhesions /
What are intrauterine adhesions,
how to treat them, protect your uterus
and regain hope for a pregnancy?
What are intrauterine adhesions / Asherman syndrome?
Intrauterine adhesions (IUA) or synechiae are fibrous bridges connecting the opposing walls of the uterus and closing the uterine cavity.
The Asherman's syndrome is the most complex form, obstructing the entire cavity.
The precise mechanism of their formation is unknown. Following a surgical intervention in the uterus, scarring of uterine wall tissue sometimes leads to the formation of IUA, regardless of the quality of the surgical procedure. IUA can appear after the following interventions:
Dilatation and curettage (D&C) for miscarriages, termination of pregnancy, retained products of conception
Uterine septum surgery
Symptoms that should alert you are the following:
Amenorrhea (having no periods)
Hypomenorrhea (very light periods)
Severe cramping or pain
Infertility (being unable to get pregnant)
IUAs are the primary mechanical cause of infertility. They can also cause repeated miscarriages and obstetrical complications. There is higher rate of spontaneous abortion, as well as preterm delivery and abnormal placentation among patients with moderate to severe disease (1,2).
IUAs are very hard to remove and repeated surgical treatment may be required (3).
How to diagnose
The best way to diagnose intrauterine adhesion is to perform a diagnostic hysteroscopy. During this procedure, your gynecologist places a small camera (a hysteroscope) through the cervix into the uterus to watch the entire uterine cavity and characterize the location, extent and type of adhesions. Diagnostic hysteroscopy can be performed in office and anesthesia is usually not required.
The only treatment option is called adhesiolysis and it is an operation performed by an expert surgeon using hysteroscopy. The surgeon reaches the inside of the uterus through the cervix with a small camera to cut the adhesions with very small scissors or electrosurgery instruments. They can be difficult to eliminate completely and staged operations are sometimes necessary.
However, IUAs often grow back: the recurrence rate after intrauterine adhesiolysis can be as high as 62.5% in case of severe disease (4).
How to avoid IUA recurrence and increase chances of pregnancy
After surgery, it is critical to ensure that the two walls of your uterus don't touch each other, as it would facilitate the formation or recurrence of IUAs. Surgeons can place hyaluronic acid gels, contraceptive intrauterine devices (IUD) or the new Womed Leaf adhesion barrier inside your uterus as a preventative measure.
Four to six weeks later, a follow-up hysteroscopy is recommended to verify that your uterus has healed properly.
A new adhesion barrier
that can help protect your uterus to
get pregnant faster.
Womed Leaf is a soft and gentle film
that can be thought of as a womb dressing
How does Womed Leaf work?
The surgeon places the film inside your uterus at the end of the surgical procedure.
This flexible film grows between the walls of your uterus to prevent them from touching each other during the healing process.
After approximately one week, it will naturally come out with your vaginal discharge. You will not feel any discomfort or pain (5).
Womed Leaf is a medical device. It is a regulated health product which has received Medical CE Mark and can only be used by a healthcare professional.
She received Womed Leaf
Léa, 33 years old
"I was told I would not be able to have children again"
I was told that I would not be able to have children again. But since the operation and the insertion of the Womed Leaf, my periods have returned to the way they were before and I can have a spontaneous pregnancy. I am so happy and grateful to have benefited from this innovation.
I want to benefit from Womed Leaf and participate to the clinical trial
Womed Leaf is currently being studied in a clinical trial and you might be able to participate to benefit from it.
This clinical trial aims to demonstrate the efficacy of Womed Leaf in reducing the recurrence of intrauterine adhesions. Several patients are already participating. Your participation in this trial is entirely voluntary.
Do you want to find out more?
Do you want to participate in the clinical trial?
List of participating hospitals
CHU Bicêtre (Paris)
CHU Lariboisière (Paris)
Hopital La Conception (Marseille)
CHRU Jeanne de Flandre (Lille)
General hospital (Pragua)
Gynprenatal (Havířov) & Gynenatal (Hlučín)
Aso Mauriziano Umberto I Torino
+33 7 49 33 50 00
Find out more and get support
Find out more about the causes of intrauterine adhesions with Prof Fernandez and an IUA patient.
A scientific article from Dr Isaacson that describes the causes, consequences, diagnostic and treatment options of intrauterine adhesions
A scientific study evaluates the rate of pregnancy following hysteroscopic management of intrauterine adhesions.
Association of infertile and sterile persons and patients and former patients using ART techniques
Do you need to talk about it? Patient support groups exist!
Discover testimonies of gynecologists and surgeons from all over the world, psychologists, midwives, patients etc.
1. Salazar et al. A comprehensive review of Asherman's syndrome: causes, symptoms and treatment options Curr Opin Obstet Gynecol 2017 Aug;29(4):249-256
2. Hooker et al. Systematic review and meta-analysis of IUA after miscarriage: prevalence, risk factors and long-term reproductive outcome Hum Reprod Update.2014;20(2):262-78
3. Fernandez et al. Total adhesions treated by hysteroscopy: must we stop at two procedures?Fertil Steril. 2012 Oct;98(4):980-5
4. Warembourg et al. Prevention and treatment of intra-uterine synechiae: Review of the literature 2015:44(4) 366-379
5. Weyers et al. Safety and Efficacy of a Novel Barrier Film to Prevent IUA Formation after Hysteroscopic Myomectomy: The PREG1 Clinical Trial JMIG 2021
Womed Leaf is manufactured by WOMED SAS. It is indicated for use in transcervical procedures.